PoursinaHakim Digestive Disease Research Center

2023

The effectiveness of extradiagnostic group therapy on the severity of symptoms and disease perception of people with irritable bowel syndrome

Background: The aim of this research was to determine the effectiveness of group therapy on the severity of symptoms and perception of the disease in people with irritable bowel syndrome. The research was a semi-experimental type with a one-month follow-up phase. The population consisted of all female patients suffering from irritable bowel syndrome.

Evaluation and comparison of therapeutic effects of probiotics and colloidal bismuth subcitrate on abdominal bloating

Background: Functional abdominal bloating is one of the functional gastrointestinal disorders (FGIDs). Here, we aimed to investigate and compare the effects of probiotics and colloidal bismuth subcitrate on abdominal bloating.

Model of Predicting Psychosocial Adaptation to Disease According to Health-Promoting Behaviors with the Mediation Role of Self-Compassion in the Patients with Irritable Bowel Syndrome

Background: The present study was conducted to offer the model of predicting psychosocial adaptation to disease according to health-promoting behaviors with the mediation role of self-compassion in the patients with Irritable Bowel Syndrome (IBS).

Comparison of the Effectiveness of Mindfulness Therapy and Interoceptive Exposure on Symptom Severity of Patients with Irritable Bowel Syndrome

Background:Irritable bowel syndrome (IBS) is a debilitating chronic disease due to major changes in the health status and lifestyle of people in recent years; it has been one of the common and significant problems in the field of healthcare and medical professionals, which requires psychological interventions besides the biological treatments due to the accompanying psychological complications. The aim of this study was to compare the effectiveness of mindfulness therapy and interoceptive exposure on symptom severity of patients with IBS.

Rescue effect of curcumin against copper toxicity

Background: Turmeric has long been used not only as an indispensable part of Asian cuisine but as a medicinal herb for dressing wounds, bites, burns, treating eye infections and acne. Curcuminoids are the active substances and their synthetic derivatives possess an incredibly wide range of medicinal properties that encompass chelation capacity for multiple heavy metals, antioxidant activity, anti-inflammatory properties, cytotoxicity against cancerous cells, antiviral and antibacterial effects, antihypertensive and insulin sensitizing role, and regulatory role on apoptosis.

The Comparison of the Effectiveness of Trans-diagnostic Treatment and the Acceptance and Commitment Therapy (ACT) on Quality of Life in Patients with Irritable Bowel Syndrome (IBS)

Background: Using new psychological approaches along with biological treatments is an effective measure to reduce secondary mental symptoms caused by biological diseases. The purpose of the present study is to compare the effectiveness of extra diagnostic treatment and treatment based on acceptance and commitment to the quality of life of patients with irritable bowel syndrome.

2021

The Comparison of the Effectiveness of Trans-diagnostic Treatment and the Acceptance and Commitment Therapy (ACT) on Emotion Regulation and Illness Perception in Patients with Irritable Bowel Syndrome (IBS)

Background: irritable bowel syndrome is the most common, costly and debilitating type of disorder among functional gastrointestinal disorders. The aim of this study was to compare the effectiveness of transdiagnostic treatment and acceptance and commitment therapy and the control group on emotion regulation and illness perception in patients with irritable bowel syndrome.

2019

Predictive value of colonic transit time indices for differentiating nonnormal from normal sensation in children with chronic functional constipation identified by anorectal manometry

Background: Constipation is a common disorder in pediatrics, although the underlying pathogenesis is not fully understood. The current study aimed at evaluating the efficacy of different colonic transit time (CTT) indices for differentiating normal from nonnormal sensation in children with chronic functional constipation identified by anorectal manometry (ARM).

Relations between Coping Skills, Symptom Severity, Psychological Symptoms, and Quality of Life in Patients with Irritable Bowel Syndrome

Background: Irritable bowel syndrome (IBS) is one of the most common functional gastrointestinal disorders with significant impact on quality of life (QOL). Considering the role of stress in the clinical course of IBS, we investigated associations between stress coping skills and symptoms and QOL in IBS patient.

Effects of Ramadan Fasting on the Symptoms of Gastroesophageal Reflux Disease

Background: The effects of Ramadan fasting on gastroesophageal reflux disease (GERD) remains unknown, and few studies have been conducted in this regard. The nutritional, physiological, psychological, and behavioral changes in fasting individuals during Ramadan may affect the status of GERD. The present study aimed to evaluate the effects of these changes on the symptoms of GERD using a meticulous method.

Comparing the Effect of Aripiprazole with Nortriptyline on Severity of Irritable Bowel Syndrome

Background: Neuropsychiatric factors play important roles in symptoms of irritable bowel syndrome (IBS). Mood disorders such as bipolar disorder are prevalent among patients with IBS. Antidepressants are used traditionally for management of IBS symptoms but antibipolar agents have not been studied. Aripiprazole, an antibipolar agent, was selected because of having the least anticholinergic side effects.

2018

Combination of diclofenac and aggressive hydration for the prevention of post-ERCP pancreatitis

Background: The aim of this study is To investigate whether aggressive hydration can increase the efficacy of prophylactic non-steroid anti-inflammatory drugs (NSAIDs) in prevention of post-ERCP pancreatitis. NSAIDs are recommended for the prevention of PEP; however, whether aggressive hydration can have additional benefits in this regard is not known.

2017

Effects of Ramadan Fasting on Dyspepsia Symptoms

Background: A few studies have shown that during Ramadan, gastrin, pepsin, and acid secretion are increased and some changes in nutrition of fasting people may deteriorate dyspepsia symptoms. On the other hand stopping smoking and alcohol use and probable psychosocial factors may improve dyspepsia symptoms.

Effectiveness of Quercus brantii hydro alcoholic extract on dyspepsia: A randomized, double blind clinical trial

Background: We aimed to evaluate the effectiveness of hydroalcoholic extract of Quercus brantii’s nut on clinical, endoscopic, and pathological fi ndings of patients with dyspepsia.

2015

Health related quality of life in irritable bowel syndrome patients, Kashan, Iran: A case control study

Background: Irritable bowel syndrome has significant impacts on the quality of life (QOL) but IBS subtypes may be different in QOL. This study aimed to assess QOL in IBS subtypes and also two prevalent questionnaires applied to evaluate the QOL in IBS.

Synbiotic containing Bacillus coagulans and fructo-oligosaccharides for functional abdominal pain in children

Background: We evaluated the effectiveness of a synbiotic in the treatment of childhood functional abdominal pain (FAP). Probiotics are effective in the treatment of functional gastrointestinal disorders in adult patients, but there is lack of information in children.

2014

Citalopram for pediatric functional abdominal pain: a randomized, placebo-controlled trial

Background: Antidepressants are effective in adults with pain-related functional gastrointestinal disorders. We investigated the effectiveness of citalopram in the treatment of childhood functional abdominal pain (FAP).

Mebeverine for Pediatric Functional Abdominal Pain: A Randomized, Placebo-Controlled Trial

Background: Few studies are conducted on the efficacy of antispasmodics in the treatment of functional gastrointestinal disorders in children. We evaluated the effectiveness of a smooth-muscle relaxant (mebeverine) in the treatment of childhood functional abdominal pain (FAP).

2013

Comparison of Lactobacillus Sporogenes plus mineral oil and mineral oil alone in the treatment of childhood functional constipation

Background: Functional constipation is one of the most prevalent childhood gastrointestinal disorders. We evaluated effects of adding a probiotic to mineral oil in the treatment of functional constipation in children.

2012

Irritable Bowel Syndrome–like Symptoms in Patients with Inflammatory Bowel Disease in Clinical Remission Phase are Related to Gut Inflammation

Background: Symptoms consistent with irritable bowel syndrome (IBS) are common among IBD patients in remission phase, and clinicians have difficulties in interpreting such symptoms as an ongoing disease activity or a coexistent IBS. We investigated if the assessment of Fecal Calprotectin (FC) could be helpful in this regard

2011

Linguistic Validation of the Irritable Bowel Syndrome-Quality of Life Questionnaire for Iranian Patients

Background: There is a growing interest of clinical and epidemiological researches in the field of functional gastrointestinal disorders in our society. Accordingly, validated and culturally adapted instruments are required for appropriate measurement of variables specially the quality of life. The aim of our study was the linguistic validation of the Irritable Bowel Syndrome-Quality of Life questionnaire (IBS-QOL) for Iranian IBS patients with Persian language

Comparing the efficacy of biofeedback and balloon-assisted training in the treatment of dyssynergic defecation

Background: Dyssynergic defecation does not respond appropriately to routine treatments for constipation. Recently, research has shown that biofeedback therapy is useful in anorectal dyssynergia. To compare two treatment modalities for patients experiencing dyssynergic defecation.

2010

The Effectiveness of Coping Strategies Training on Symptom Severity, Quality of Life and Psychological Symptoms among Patients with Irritable Bowel Syndrome

Background: Various psychological interventions were considered as part of the treatments of irritable bowel syndrome. However, the effectiveness of coping strategies in improving symptoms of this disease remains unclear. The objective of this study was to assess the effects of coping strategies training in treatment of irritable bowel syndrome (IBS).

2009

Which End Point Is More Comprehensive in Refl ecting Changes in Irritable Bowel Syndrome Treatment Trials?

2008

Is microscopic colitis a missed diagnosis in diarrhea-predominant Irritable Bowel Syndrome?

Background: There are controversies about the importance of biopsies of normal colon mucosa in the investigation of patients with diarrhea predominant irritable bowel syndrome (IBS). On the other hand, microscopic colitis may be missed based on normal colonoscopy and laboratory examination in this group of patients

2007

Colonoscopic diagnosis of appendiceal intussusception in a patient with intermittent abdominal pain: A case report

Background: Intussusception of the appendix is a rare condition. Most cases are diagnosed during operation of the patients suspected to have appendicitis. In this report we present a seventy one year-old man with a history of periumbilical intermittent abdominal pain for several months.

2006

Where Does Hypnotherapy Stand in the Management of Irritable Bowel Syndrome? A Systematic Review

Background: Irritable bowel syndrome (IBS) is a gastrointestinal disorder characterized by chronic abdominal pain and altered bowel habits in the absence of any organic cause. Despite its prevalence, there remains a significant lack of efficient medical treatment for IBS to date. However, according to some previous research studies, hypnosis has been shown to be effective in the treatment of IBS. To determine the definite efficacy of hypnosis in the treatment of irritable bowel syndrome.

Airway resistance in irritable bowel syndrome as measured by impulse oscillometry

Background: Irritable bowel syndrome (IBS) is associated with bronchial asthma. However, published data on airway resistance or impedance in patients with IBS but without any respiratory symptoms are lacking.

Effects of Ramadan fasting on acute upper gastrointestinal bleeding due to peptic ulcer

Background: As, acid negatively affects duodenal and gastric mucosal defense, we designed this study to investigate if fasting during Ramadan can promote peptic ulcer and its complication, acute upper gastrointestinal bleeding.

Research Projects

Complete

Combination of diclofenac and aggressive hydration for the prevention of post-ERCP pancreatitis

PI: Mehri Hajalikhani, MD
Colleagues: Mahsa Khodadoustan, Mohammad Hassan Emami, MD
Funded by: Poursina Hakim Digestive Disease Research Center, Isfahan University of Medical Sciences

http://journals.sbmu.ac.ir/ghfbb/index.php/ghfbb/article/view/1424

The structural pattern of the relationship between the Severity of symptoms, Illness perception and Resilience with Health-related quality of life in IBS patient

PI: Ghazale Teymouri
Colleagues: Elnaz Sajadyan, MD
Funded by: Islamic Azad University Isfahan (Khorasgan) Branch Research Center

Comparison of the effects of Aripiprazole with Nortriptyline on Irritable bowel syndrome

PI: Hojatolah Rahimi, MD
Colleagues: Seyed Mohammad Hassan Emami, MD
Funded by: Poursina Hakim Digestive Disease Research Center

The effect of fasting on symptoms of reflux disease in 2015 and 2016 in Isfahan

PI: Hojatolah Rahimi, MD
Colleagues: Seyed Mohammad Hassan Emami, MD
Funded by: Poursina Hakim Digestive Disease Research Center

Relationship between stress-coping strategies with severity of gastrointestinal symptoms, psychological factors and quality of life in patients with irritable bowel syndrome

PI: Mehrdad Zeynalian, MD
Colleagues: Seyed Mohammad Hassan Emami, MD

Sleep hygiene knowledge and practice in association with sleep quality in patients with irritable bowel syndrome

PI: Leyla Mirbagher
Colleagues: Seyed Mohammad Hassan Emami, MD

Evaluting the effect of Simethicone on decreasing foam and bubbles during upper gastrointestinal endoscopy

PI: Farnaz Torkzade
Colleagues: Seyed Mohammad Hassan Emami, MD

Evaluation of effectiveness of Fluoxetine on symptom and Quality of Life in Patients with Irritable Bowel Syndrome

PI: Forough Ghasedi. Ali Gholamrezai
Colleagues: Seyed Mohammad Hassan Emami, MD. Khoram, MD. Adilipour,MD. Tavakoli,MD

Evaluation of effectiveness of citalopram on symptoms and quality of life of patients with irritable bowel syndrome

PI: Hamid Tavakoli, MD
Colleagues: Seyed Mohammad Hassan Emami, MD. Khoram, MD. Adilipour,MD. Gholamrezai, MD

Evaluation of the Prevalence of Gastrointestinal Disorders in Isfahan

PI: Falah, MD. Abutalaian, MD
Colleagues: Seyed Mohammad Hassan Emami, MD. Khoram, MD. Adilipour,MD. Tavakoli,MD. Kabiri, MD. Talaei, MD.Farajzadegan, MD. Adibi, MD. Gholamrezai, MD

Evaluation of effectiveness of Yoga on Symptom and Quality of Life in Patients with Irritable Bowel Syndrome

PI: Atati, MD
Colleagues:Mohammad Hassan Emami, MD. Khoram, MD. Adilipour,MD. Tavakoli,MD. Gholamrezai, MD

Evaluation of effectiveness of hypnotherapy on the symptoms and quality of life of patients with irritable bowel syndrome

PI: Gholamrezai, MD
Colleagues: Seyed Mohammad Hassan Emami, MD. Khoram, MD. Adilipour,MD. Tavakoli,MD

Evaluation of effectiveness of recovery expectation and belief in cure in response to psychological treatment of irritable bowel syndrome

PI: Gholamrezai, MD
Colleagues: Seyed Mohammad Hassan Emami, MD. Nemati, MD. Daghaghzade, MD

Predicting the prognosis of Balloon Dilation therapy in Achalasia patients, Using a Novel Visual Scale

PI: Mehran Haghighi
Colleagues: Seyed Mohammad Hassan Emami, MD

Determination of Pulmonary Airway Resistance in Patients with Irritable Bowel Syndrome (Al-Zahra Hospital, Bamdad clinic 2004-2005)

PI: Behzad Dourshi
Colleagues: Babak Amra, MD

Study of the validation of irritable bowel syndrome quality of life questionnaire (IBS-QOL) for Iranian patients

PI: Ali Afshari
Colleagues: Seyed Mohammad Hassan Emami, MD

Determination of prevalence of causes of GIB and its treatment in patients hospitalized in Al- Zahra hospital of Isfahan in 1998

PI: Ali Afshari
Colleagues: Seyed Mohammad Hassan Emami, MD

Reflux and its effect on the severity of respiratory diseases- 2005- Chemical War Veterans of Isfahan 2006

PI: Bijan Ebrahimi, MD
Colleagues: Seyed Mohammad Hassan Emami, MD

The effect of fasting on dyspepsia symptom in 2015 and 2016 in Isfahan

PI: Hojatollah Rahimi, MD
Colleagues: Seyed Mohammad Hassan Emami, MD
Funded by: Poursina Hakim Digestive Disease Research Center

Evaluation of effectiveness of Fluvoxamine on Symptoms and Quality of Life in Patients with Irritable Bowel Syndrome

PI: Agah, MD
Colleagues: Seyed Mohammad Hassan Emami, MD. Gholamrezai,MD

Evaluation of diagnostic value of alarm symptoms, dyspepsia and endoscopy in compared with Biopsy

PI: Masoud Ataei, MD
Colleagues: Seyed Mohammad Hassan Emami, MD
Funded by: Poursina Hakim Digestive Disease Research Center, Isfahan University of Medical Sciences

Comparison of Candida colonization in the esophagus and stomach of patients taking proton pump inhibitors drugs with histamine receptor antagonist in Isfahan during 2019-2020

PI: Batoul Motaghi

Colleagues: Rasoul Mohammadi. Ph.D, Mohamad Hassan Emami. MD

The Comparison of the Effectiveness of Transdiagnostic Treatment and the Acceptance and Commitment Therapy (ACT) on Emotion Regulation, Illness Perception, Helth Locus of Control, and the Quality of Life in Patients with Irritable Bowel Syndrome (IBS)

PI: Zahra Karimyan
Colleagues: Abbas Haghayegh. Ph.D, Mohamad Hassan Emami. MD. Mostafa Raisi, MD

The effectiveness of short-term psychological training on the ability of mindfulness, anxiety sensitivity and symptoms of patients with irritable bowel syndrome

PI: Niloufar Nikgoftar, Medical Student
Colleagues: Fatemeh Zargar, MD

Ongoing

Pneumatic Balloon Dilatation for Achalasia Cardia : outcome , complications , success . an extended follow up

PI: Farnoush Ahmadyan, Medical Student

Colleagues: Mohammad Hassan Emami, MD

Structural model of psychosocial adaptation to illness based on perceived stress, health-promoting behaviors and mental coherence with self-compassion mediated in patients with irritable bowel syndrome

PI: Farzaneh Forouzanfar, PhD

Colleagues: Mojtabah Ansari Shahidi, Ph.D, Sheyda Jabalameli Ph.D, Mohammad Soltanizadeh Ph.D, Mohammad Hassan Emami, MD.

Investigation of frequency, survival and risk factors of primary sclerosing cholangitis in patients who admitted to Poursina-Hakim clinic in Isfahan between 2002-2023

PI: Reza Ebrahimi, Medical Student
Colleagues: Mohammad Hassan Emami, MD. Fatemeh Maghool PhD, Masoud Moghtaderi MD, Reza Solouki MD, Abdolmehdi Baghaei MD, Amirhosein Hekmat, Medical Student, Anasik Lalazaryan MS

FGID DEPARTMENT