Colorectal cancer (CRC) is the third most common cancer worldwide. The global burden of CRC is rising, with 2.2 million predicted new cases (and 1.1million deaths) by 2030. Prospective cohort studies can provide reliable assessment of the complex interaction of genetic and environmental/ lifestyle factors as causes of CRC. The Poursina Hakim Biobank (PHB), contains multiple human tissues (FFPE and fresh frozen), serum, plasma, whole blood, DNA, and RNA samples all set up to explore the main genetic and environmental causes of CRC in the Iranian population. PHB is pleased to collaborate with research groups in international projects.